inhibition – Communicable Diseases Research

Folic acid: a potential inhibitor against SARS-CoV-2 nucleocapsid protein

엽산: SARS-CoV-2 뉴클레오캡시드 단백질에 대한 잠재적 억제제

Article

Published on 2022-12-012022-09-11
Journal: Pharmaceutical Biology
[Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법,

[키워드] analysed Analysis antagonist antiviral effects antivirus association cellular Chinese Chinese medicine Compound Concentration coronavirus disease Coronavirus disease 2019 COVID-19 Data analysis docking drug target experiment Folic acid Genes global pandemic Host hub genes identify inhibit inhibition inhibitor involved material mCherry mCherry expression mechanism molecular molecular docking network pharmacology Network pharmacology. Nucleocapsid phosphoprotein Phosphoprotein Protein Regulatory RNA interference RNAi SARS-CoV-2 SARS-CoV-2 N SARS-CoV-2 nucleocapsid screened shown target targets therapeutic target Traditional Traditional Chinese medicine virus
[DOI] 10.1080/13880209.2022.2063341 PMC 바로가기 [Article Type] Article

Zinc pyrithione is a potent inhibitor of PL Pro and cathepsin L enzymes with ex vivo inhibition of SARS-CoV-2 entry and replication

아연 피리티온은 SARS-CoV-2 진입 및 복제를 생체 외에서 억제하는 PL Pro 및 카텝신 L 효소의 강력한 억제제입니다.

Article

Published on 2022-12-012022-09-11
Journal: Journal of Enzyme Inhibition and Medicinal Chemist
[Category] COVID19(2023년), SARS, 치료제,

Robust neutralizing antibody response to SARS-CoV-2 mRNA vaccination in adolescents and young adults with childhood-onset rheumatic diseases

Article

Published on 2022-11-022022-11-15
Journal: Rheumatology (Oxford, England)
[Category] SARS, 진단, 치료기술,

[키워드] adverse event childhood-onset rheumatic disease Chinese Cohort COVID-19 COVID-19 infection cPass™ cut-off defined disease Disease activity dose Efficacy evaluate female first vaccination humoral immunogenicity immunogenicity increased the risk inhibition median medication Most patient mounted mRNA vaccination mRNA vaccine neutralization Neutralizing antibodies Neutralizing antibody response neutralizing response not affect Paediatric age paediatric rheumatology Patient positive predictor proportion remained response rheumatic disease SARS-CoV-2 SARS-CoV-2 vaccine second vaccination Serious Adverse Event serious complication Seven Subgroup analysis symptomatic the SARS-CoV-2 the vaccine two-dose regimen vaccination Vaccine vaccine efficacy vaccine safety. were assessed
[DOI] 10.1093/rheumatology/keac105 PMC 바로가기

Therapeutic potential of metal ions for COVID-19: insights from the papain-like protease of SARS-CoV-2

Article

Published on 2022-10-282023-07-10
Journal: Biochemical Journal
[Category] COVID19(2023년),

[키워드] COVID-19 EDTA inhibition metal ions papain-like protease. SARS-CoV-2
[DOI] 10.1042/BCJ20220380 PMC 바로가기

Interaction of HDAC2 with SARS-CoV-2 NSP5 and IRF3 Is Not Required for NSP5-Mediated Inhibition of Type I Interferon Signaling Pathway

Article

Published on 2022-10-262022-11-15
Journal: Microbiology Spectrum
[Category] COVID19(2023년), SARS, 치료제,

[키워드] abrogate activated addition bind binding biological significance cellular processe complex disrupt DNA Epigenetic Evidence expression favor Gene Expression HDAC2 Host host antiviral response IFN response IFN signaling pathway IFN-stimulated genes IFNβ IL-1β IL-6 immune response gene inhibit inhibition inhibitory interact Interaction interferons involved IRF3 nsp5 over Pathogenesis pathway promote promoter promoters protease Protease activity protein interaction protein-protein interactions reduce Regulation Replication repress required RNA SARS-CoV-2 SARS-CoV-2 protein Signaling signaling pathway significantly subset Type Type I IFN type I IFN signaling. type I interferon viral infection viral infections Viral protein virus
[DOI] 10.1128/spectrum.02322-22 PMC 바로가기

Correlation of SARS-CoV-2 Viral Neutralizing Antibody Titers with Anti-Spike Antibodies and ACE-2 Inhibition among Vaccinated Individuals

Article

Published on 2022-10-262022-11-15
Journal: Microbiology Spectrum
[Category] COVID19(2023년), SARS, 진단,

[키워드] ACE-2 ACE2 ACE2 binding analyzed Angiotensin converting enzyme-2 Anti-RBD IgG Anti-spike anti-spike antibody anti-Spike IgG antibody binding blood collection BNT162b2 calculated collected Concentration correlated correlation correlation coefficient correlation coefficients COVID-19 COVID-19 antibody demonstrated dosing interval examined Fisher group groups IgG individual inhibition interval intervals labor-intensive measure mRNA mRNA-1273 vaccines Neutralizing antibodies neutralizing antibodies. neutralizing antibody Neutralizing antibody titer neutralizing antibody titers NTD Participants performed RBD Sample SARS-CoV-2 Secondary analyses Spearman correlation coefficient subgroup tested the median the vaccine titer vaccinated individual vaccination Vaccine vaccinee vaccinees Validity viral neutralization wild-type with COVID-19 women
[DOI] 10.1128/spectrum.01315-22 PMC 바로가기

Inhibition of the Cell Uptake of Delta and Omicron SARS-CoV-2 Pseudoviruses by N-Acetylcysteine Irrespective of the Oxidoreductive Environment

Article

Published on 2022-10-212022-11-16
Journal: Cells
[Category] COVID19(2023년), SARS, 변종,

[키워드] ACE2 ACE2-expressing cell ACE2-expressing cells addition Affect alteration angiotensin-converting enzyme 2 antioxidant approach ascorbic acid binding Cell cell internalization cell receptor Comorbidities COVID-19 Delta dose-dependent Effect Effects Environment evaluated hydrogen peroxide inhibit inhibited inhibition mechanism N-acetyl-L-cysteine N-acetylcysteine NAC omicron Oxidant pharmacological Previous studies produced pseudovirus reactive oxygen species Reactive oxygen species. reactive oxygen specy respiratory viral infection risk ROS SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 spike therapy uptake variant variants variants of SARS-CoV-2 virus uptake
[DOI] 10.3390/cells11203313 PMC 바로가기

Reactive Centre Loop Mutagenesis of SerpinB3 to Target TMPRSS2 and Furin: Inhibition of SARS-CoV-2 Cell Entry and Replication

Article

Published on 2022-10-192022-11-15
Journal: International Journal of Molecular Sciences
[Category] COVID19(2023년), SARS, 변종, 치료제,

[키워드] Alpha Altered Anti-viral Anti-viral therapy Antiviral assays biological molecules cathepsin L Cell cell entry cellular proteases cleaved designer serpin effective enzyme expressing facilitate furin furin. generate host cell protease implicated in vitro infection with SARS-CoV-2 inhibit inhibition inhibitor inhibitors inhibitory inhibitory activity loop membrane fusion Mutagenesis P681R predicted produced protease Protein purified rate constant reactive Recombinant protein S protein cleavage S1/S2 cleavage site SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 viral replication SARS-CoV-2 virus serine 2 serine protease inhibitor SerpinB3 shown specificity suppress target the Spike the spike protein TMPRSS2 transmembrane variant Vero E6 cell
[DOI] 10.3390/ijms232012522 PMC 바로가기

Comparative Assessment of the Inhibitory Potential of the Herbicide Glyphosate and Its Structural Analogs on RGD-Specific Integrins Using Enzyme-Linked Immunosorbent Assays

Article

Published on 2022-10-172022-11-16
Journal: International Journal of Molecular Sciences
[Category] COVID19(2023년), SARS, 치료기술,

Inhibition of major histocompatibility complex-I antigen presentation by sarbecovirus ORF7a proteins

Article

Published on 2022-10-112022-11-16
Journal: Proceedings of the National Academy of Sciences of
[Category] COVID19(2023년), SARS, 유전자 메커니즘,